polymorphs, solvates and co-crystals. Functional groups that are self-complementary are capable of forming either a supramolecular homosynthons (eg-acid-acid and amide-amide homodimers or a supramolecular heterosynthon (carboxylicacid-amide heterodimers)
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چکیده
The emerging role of supramolecular chemistry and crystal engineering in pharmaceutical science has been influenced significantly by the interest in pharmaceutical cocrystals. Pharmaceutical co-crystals are co-crystals that are formed between an API (active pharmaceutical ingredient) and a co-crystal former that is a solid under ambient conditions. APIs contain functional groups that engage in more than one supramolecular event with itself, a solvent molecule or co-crystal former thereby forming polymorphs, solvates or co-crystals respectively. There are two types of molecular recognition facilitating the formation of polymorphs, solvates and co-crystals. Functional groups that are self-complementary are capable of forming either a supramolecular homosynthons (eg-acid-acid and amide-amide homodimers or a supramolecular heterosynthon (carboxylicacid-amide heterodimers) 144 . The knowledge of co-crystals is very important in the design of multicomponent pharmaceutical solids 145.
منابع مشابه
Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.
The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.
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